A new bioconjugation strategy developed at ICMUB has just been published in the Journal of the American Chemical Society (JACS), one of the leading international journals in chemistry.
The researchers developed a new family of heterocycles, 1,3,4-thiadiazole-N-oxides (TNO), and demonstrated that these can react in a novel way with constrained alkynes, giving rise to a new “click chemistry” coupling reaction, dubbed SPATOC. This fast and biocompatible reaction makes it possible to attach two functional molecules to the same site on an antibody.
This study, conducted at ICMUB and led by Dr. Victor Goncalves, unveils a new bioorthogonal chemistry platform that expands the range of tools available for the precise and efficient modification of proteins.
🔗 Read the article « Unexpected Reactivity of 1,3,4-Thiadiazole-N-oxides with Strained Alkynes Enables Enhanced Antibody Loading » : J. Am. Chem. Soc. 2026, 148, 34615–34625