Montant de l’aide (ICMUB) : €
Durée : Oct. 22 – 48 mois
Responsable scientifique : David MONCHAUD
Descriptif du projet
RNA G-Quadruplexes (rG4s) are non-canonical RNA secondary structures that play regulatory roles in many cellular processes, including in stress response. Stress Granules (SGs) are transient, cytoplasmic membraneless condensates, composed of proteins and untranslated mRNAs. Although RNA-binding proteins that may control rG4s were recently speculated to regulate SG assembly, it is unknown if rG4s play a direct regulatory role in SG biology. The Hornstein lab is expert in RNA biology and stress granule proteomics. The Monchaud lab is expert in G4 chemistry and develops chemical biology tools for rG4 research. In the current Weizmann-CNRS application, we propose to study rG4s impact on SG composition and dynamics; to develop and establish specific reagents for rG4 and rG4BPs characterization in human cells; and to discover rG4BPs as regulators of SG dynamics. This study thus aims at gaining better mechanistic understanding of both SG and rG4s biology.
Partenaires :
- Eran Hornstein, WIS Rehovot, IS