Sheet of MONCHAUD David

MONCHAUD David
Address : ICMUB Institut de Chimie Moléculaire de l'Université de Bourgogne
Bât. MIRANDE - Aille B - Bureau B-R16
9 Avenue Alain Savary
21000 Dijon – France
Phone number : (+33) 380 399 043
E-mail : david.monchaud@cnrs.fr
Team : SMol
Function : CNRS Research Director
Tags : Chemical biology, Molecular imaging, Photophysics, Synthetic chemistry
ORCID : 0000-0002-3056-9295
Scopus Author ID : 6506084183
  • Career
  • Project
  • Publications
  • Communications
  • Training et Administration
Career

2017 : CNRS Senior researcher (DR CNRS), ICMUB, CNRS UMR6302, Université de Bourgogne (Dijon, France).

2011 : Accreditation to Supervise Research diploma (i.e. Habilitation à Diriger des Recherches, HDR), ICMUB, CNRS UMR5260, Université de Bourgogne (Dijon, France).

2009 : CNRS researcher (CR CNRS), ICMUB, CNRS UMR5260, Université de Bourgogne. Lab of Pr. Franck Denat (Dijon, France).

2007 : CNRS researcher (CR CNRS), Curie Institute, CNRS UMR176. Lab of Dr. Marie-Paule Teulade-Fichou (Orsay, France).

2005 : CNRS researcher (CR CNRS), Collège de France, CNRS UPR285. Lab of Prof. Jean-Marie Lehn & Dr. M.-P. Teulade-Fichou (Paris, France).

2004 : Post-doctoral fellow (CNRS – Sanofi-Aventis grant), Collège de France. Lab of Prof. J.-M. Lehn, Dr. M.-P. Teulade-Fichou and Patrick Mailliet (Paris, France).

2003 : Post-doctoral fellow PharmaLEADS, (Paris, France).

2002 : Ph.D. in Chemistry, University of Geneva. Lab of Prof. Jérôme Lacour (Geneva, Switzerland).

Project

2026-29:   Région BFC – ICE PhD program: IMPALA II: Innovation Moléculaire Pour les Affections Liées à l’Age  (PI).

2026-29:   PhD grant – FCT Portugal: Uncovering the Role of G-quadruplexes in the Regulation of PD-L1 Expression in Lung Cancer (Co-PI avec C. Cruz, Covilha, PT)

2025-28:   INSERM PCSI: TWJ-vs-MSI: Optimized Three-Way Junction Ligands for the treatment of micro-satellite instable cancers (CoI; PI: S. Britton, IPBS Toulouse)

2024-29:   CNRS: PI and Coordinateur of the International Research Network (IRN) ‘Nucleic acid junctions’ 

2024-28:   ANR: TOP2G4: Understanding & tuning the cellular properties of G4 ligands (CoI; PI: S. Britton, IPBS Toulouse)

2024-27:   Région BFC – ICE PhD program: IMPALA: Innovation Moléculaire Pour les Affections Liées à l’Age  (PI).

2024-25:   CNRS Innovation: MoBiDiC: Molecular, Biomimetic probes for the Diagnosis of Cancers  (PI).

2023-26: Pediatric Osteosarcoma (CoI; PI: V. Géli, CRCM FR). Ligue contre le Cancer

2022-25: InJUNCTION: Chemical tools for investigating DNA junctions (PI). ANR

2022-25: G4s in Stress Granules: Co-PI with Eran Hornstein (Dpt. of Molecular Genetics, Rehovot, IS). WIS/CNRS grant, CNRS MITI.

2021-23: ANASTASIA: Alternative nucleic acid structures stabilization triggers replicative stress and induce apoptosis (PI). ISITE BFC (UB21018.MUB.IS)

2020-24: G4s in NVUs: G4-DNA as senescence markers in the neurovascular unit (CoI; PI: A. S. Tsvetkov, UThealth, TX USA). NIH (NIH R01 PAR-19-070)

2019-22: SEQUENTIA: Sequencing technologies adapted to the study of dementia (PI). FEDER-FSE Bourgogne 2014-2020.

2019-21: ANASTOMOSIS: Alternative Nucleic Acid Structures as Targets for Organic Molecules to Orchestrate Sustained genomic Instability and cellular Stress (PI). Plan Cancer 2014-2020 INSERM.

2019-21 : CoolCat: Constrained oligonucleotide-based catalysts (CoI). ANR (ANR-18-CE07-0017-03).

2018-20 : DEMENTIA: Exploiting genetic biomarkers of neurodegenerative diseases for developing early diagnostic tests and possible treatments (PI). ANR (ANR-17-CE17-0010-01).

2017-19 : STARFISH DNA: Stalling the Replication Fork via the Impedimental Stabilization of Higher-order DNAs (PI). European Commission (H2020-MSCA-IF-2016-750368).

2015-16 : Des sondes fluorescentes intelligentes pour déchiffrer le mécanisme d’action in cellulo d’agents anti-cancéreux (PI). FEDER (PARI2-DS3-2015).

2010-13 : TuMOR TAG: Tumor-specific multi-operating radiotracers targeting telomerase and G-quadruplex (PI) ANR (ANR-10-JCJC-709-1).

2010 : Unusual DNA structures as novel targets for anticancer therapy (PI). Programmes Interdisciplinaires CNRS (PIR-AO2-2010).

2008-10 : Development of molecular tools for imaging all types of cancers (PI). FABER (Conseil Régional de Bourgogne, FABER-2009-149E-149CE)

Publications
Shijiong Wei, Xinrong Yan, Bin Liu, Dehui Qiu, Jean-Louis Mergny, et al.. Discriminating G-quadruplex topologies by bright-field microscopy. Science China Chemistry, 2026, 69, pp.5315 - 5321. ⟨10.1007/s11426-026-3488-0⟩. ⟨hal-05801654⟩
Rocio Diaz Escarcega, Vijay Kumar M. J, Ashlee Arizmendez, Chunfeng Tan, Akihiko Urayama, et al.. Sex-linked helicases DDX3X and DDX3Y regulate G-quadruplex-associated stress in neurons. Cell Death and Disease, 2026, 17, pp.820. ⟨10.1038/s41419-026-08971-z⟩. ⟨hal-05801648⟩
Anne de Cian, Gael Cristofari, Patrick Reichenbach, Elsa de Lemos, David Monchaud, et al.. Reevaluation of telomerase inhibition by quadruplex ligands and their mechanisms of action. Proceedings of the National Academy of Sciences of the United States of America, 2007, 104 (44), pp.17347-17352. ⟨10.1073/pnas.0707365104⟩. ⟨hal-02124563⟩
Daniela Alexandre, Alexandra R Fernandes, Robert H.E. Hudson, David Monchaud, Pedro V Baptista, et al.. Modulating PhpC bioavailability and cellular activity in lung cancer cells via gold nanoparticle functionalization. Journal of Drug Delivery Science and Technology, 2026, 122, pp.108457. ⟨10.1016/j.jddst.2026.108457⟩. ⟨hal-05626959⟩
Garance Psalmon, Angélique Pipier, Manon Barbotte, Robert H E Hudson, Stephen Neidle, et al.. DNA damaging properties of G-quadruplex ligand QN-302 are potentiated by the DNA repair inhibitor Olaparib and mitigated by the molecular helicase PhpC. Genome Biology, 2026, 27 (1), pp.168. ⟨10.1186/s13059-026-04035-9⟩. ⟨hal-05626955⟩
David Monchaud. 1950–2000: five decades of curiosity-driven discovery in alternative DNA structures. Nucleic Acids Research, 2026, 54 (8), pp.gkag366,. ⟨10.1093/nar/gkag366⟩. ⟨hal-05626952⟩
Dehui Qiu, Xiaobo Zhang, Fan Tian, Yuan Liu, Fangni He, et al.. Designing an ecofriendly catalyst for a sustainable use of water resources. National Science Review, 2025, 13 (2), pp.nwaf447. ⟨10.1093/nsr/nwaf447⟩. ⟨hal-05492278⟩
Jianjun Xia, Jiahang Zhou, Xinzhe Zhuang, Huangxian Ju, David Monchaud, et al.. Deciphering the intermolecular interactions between G-quadruplex (G4)-forming sequences. Nucleic Acids Research, 2025, 53 (22), ⟨10.1093/nar/gkaf1288⟩. ⟨hal-05403868⟩
Sandy Raevens, Cécile Desingle, Marc Pirrotta, Francesco Rota Sperti, Andréa Pieri, et al.. Convergent Synthesis of Template‐Assembled Synthetic G‐Quartets (TASQs) Used as Biomimetic and Multivalent G‐Quadruplex (G4) Ligands. Chemistry - A European Journal, 2025, pp.e03002. ⟨10.1002/chem.202503002⟩. ⟨hal-05384162⟩
Sandy Raevens, Yehuda Danino, Cécile Desingle, Francesco Rota Sperti, Marc Pirrotta, et al.. Photoactivatable, Biomimetic Ligand photoMultiTASQ Traps DNA/RNA G-Quadruplexes and Their Protein Binding Partners. ACS Bio & Med Chem Au, 2025, ⟨10.1021/acsbiomedchemau.5c00162⟩. ⟨hal-05343353⟩

Communications

>35 invited lectures ; >40 posters

Science popularization articles in Medecine/Sciences, Journal du CNRS and Encylopaedia Universalis

Highlights in CNRS News, CNRS, Science & Avenir and Pour La Science

Recommended by the F-1000 in 2011, 2013 et 2018

Covers for New J. Chem., Chem. Eur. J., Nucleic Acids Res., Eur. J. Org. Chem and RSC Chem. Biol.

In interview for CQFD, radio broadcast of the RTS (Radio Télévision Suisse): here

Training et Administration

Training

« Chemistry & nucleic acids » (2h/year, M2 MMHD, Dijon, since 2017).

« Chemistry & cancers » (2h/year, M2R SCM, Dijon, since 2017).

« Chemistry & translational research in oncology » (4h/an, EPHE Dijon, since 2012).

 

Administration

>500 reviewed articles for >80 different journals; cf. WoS profile

Jury for associate professor positions : 32MCF4173 (ICMUB, Dijon, 2013), 32MCF0246 (ICMUB, Dijon, 2012), 85MCF1850 (Université Paris Descartes, Paris, 2010), 32MCF0255 (ICMUB, Dijon, 2010).

Jury for HDR : R. Haudecoeur, DPM Grenoble, 2020; T. Caneque, Institut Curie, Paris, 2019; D. Gomez, IPBS Toulouse, 2017.

Jury for PhD thesis : Lab. D. Verga/JL. Mergny, IP Paris, 2023; Lab. S. Amrane, IECB Bordeaux 2022; Lab. T. Lavergne, UGA Grenoble, 2022; Lab. S. Ladame, Imperial College London (UK), 2021; Lab. C. Cruz Univ. Lisboa (PT) 2020; Lab. G. Salgado, IECB Bordeaux, 2019; Lab. O. Sénèque, CEA Grenobe, 2019; Lab. J.-L. Mergny, IECB Bordeaux, 2018 ; Lab. S. Richter, Unvi. Padova (IT), 2018; Lab. B. Therrien, Univ. Neuchatel (CH), 2018; Lab. M. Demeunynck, DPM Grenoble, 2016 ; Lab. J.-L. Mergny, IECB Bordeaux, 2016 ; Lab. F. Bolze, Strasbourg, 2015 ; Lab. R. Rodriguez, Gif/Yvette, 2015

Jury for Master 1 & 2 : ICMUB, Dijon, Juin 2021, 2020, 2012, 2013 & 2009 ; for M.Phil : Imperial College London (U.K.), Juin 2014.

Expert for funding agencies : European Research Council (ERC), Agence Nationale de la Recherche (ANR, France), Biotechnology and Biological Sciences Research Council (BBSRC, UK), Natural Sciences and Engineering Research Council (NSERC, Canada), Genesis Oncology Trust (New Zealand), Czech Academy of Science (CAS, Czech Republic), CEFIPRA (France & India), European Science Foundation (ESF, France).