Sheet of MONCHAUD David

MONCHAUD David
Address : ICMUB Institut de Chimie Moléculaire de l'Université de Bourgogne
Bât. MIRANDE - Aille B - Bureau B-R16
9 Avenue Alain Savary
21000 Dijon – France
Phone number : (+33) 380 399 043
E-mail : david.monchaud@cnrs.fr
Team : SMol
Function : CNRS Research Director
Tags : Chemical biology, Molecular imaging, Photophysics, Synthetic chemistry
ORCID : 0000-0002-3056-9295
Scopus Author ID : 6506084183
  • Career
  • Project
  • Publications
  • Communications
  • Training et Administration
Career

2017 : CNRS Senior researcher (DR CNRS), ICMUB, CNRS UMR6302, Université de Bourgogne (Dijon, France).

2011 : Accreditation to Supervise Research diploma (i.e. Habilitation à Diriger des Recherches, HDR), ICMUB, CNRS UMR5260, Université de Bourgogne (Dijon, France).

2009 : CNRS researcher (CR CNRS), ICMUB, CNRS UMR5260, Université de Bourgogne. Lab of Pr. Franck Denat (Dijon, France).

2007 : CNRS researcher (CR CNRS), Curie Institute, CNRS UMR176. Lab of Dr. Marie-Paule Teulade-Fichou (Orsay, France).

2005 : CNRS researcher (CR CNRS), Collège de France, CNRS UPR285. Lab of Prof. Jean-Marie Lehn & Dr. M.-P. Teulade-Fichou (Paris, France).

2004 : Post-doctoral fellow (CNRS – Sanofi-Aventis grant), Collège de France. Lab of Prof. J.-M. Lehn, Dr. M.-P. Teulade-Fichou and Patrick Mailliet (Paris, France).

2003 : Post-doctoral fellow PharmaLEADS, (Paris, France).

2002 : Ph.D. in Chemistry, University of Geneva. Lab of Prof. Jérôme Lacour (Geneva, Switzerland).

Project

2023-26: Pediatric Osteosarcoma (CoI; PI: V. Géli, CRCM FR). Ligue contre le Cancer

2022-25: InJUNCTION: Chemical tools for investigating DNA junctions (PI). ANR

2022-25: G4s in Stress Granules: Co-PI with Eran Hornstein (Dpt. of Molecular Genetics, Rehovot, IS). WIS/CNRS grant, CNRS MITI.

2021-23: ANASTASIA: Alternative nucleic acid structures stabilization triggers replicative stress and induce apoptosis (PI). ISITE BFC (UB21018.MUB.IS)

2020-24: G4s in NVUs: G4-DNA as senescence markers in the neurovascular unit (CoI; PI: A. S. Tsvetkov, UThealth, TX USA). NIH (NIH R01 PAR-19-070)

2019-22: SEQUENTIA: Sequencing technologies adapted to the study of dementia (PI). FEDER-FSE Bourgogne 2014-2020.

2019-21: ANASTOMOSIS: Alternative Nucleic Acid Structures as Targets for Organic Molecules to Orchestrate Sustained genomic Instability and cellular Stress (PI). Plan Cancer 2014-2020 INSERM.

2019-21 : CoolCat: Constrained oligonucleotide-based catalysts (CoI). ANR (ANR-18-CE07-0017-03).

2018-20 : DEMENTIA: Exploiting genetic biomarkers of neurodegenerative diseases for developing early diagnostic tests and possible treatments (PI). ANR (ANR-17-CE17-0010-01).

2017-19 : STARFISH DNA: Stalling the Replication Fork via the Impedimental Stabilization of Higher-order DNAs (PI). European Commission (H2020-MSCA-IF-2016-750368).

2015-16 : Des sondes fluorescentes intelligentes pour déchiffrer le mécanisme d’action in cellulo d’agents anti-cancéreux (PI). FEDER (PARI2-DS3-2015).

2010-13 : TuMOR TAG: Tumor-specific multi-operating radiotracers targeting telomerase and G-quadruplex (PI) ANR (ANR-10-JCJC-709-1).

2010 : Unusual DNA structures as novel targets for anticancer therapy (PI). Programmes Interdisciplinaires CNRS (PIR-AO2-2010).

2008-10 : Development of molecular tools for imaging all types of cancers (PI). FABER (Conseil Régional de Bourgogne, FABER-2009-149E-149CE)

Publications

>110 published articles : cf. list

1 book edited : Biological relevance & therapeutic applications of DNA- and RNA-quadruplexes (Ed. D. Monchaud) © 2015 Future Science, Ltd.

2 patents : WO2010049915, WO2021198239

10 key publications:

UV-induced G4 DNA structures recruit ZRF1 which prevents UV-induced senescence. Alessio De Magis, Michaela Limmer, Venkat Mudiyam, David Monchaud, Stefan Juranek, Katrin Paeschke. Nat. Commun. 2023, 14, 6705

Template-assembled synthetic G-quartets (TASQs): multiTASQing molecular tools for investigating DNA and RNA G-quadruplex biology. David Monchaud. Acc. Chem. Res. 2023, 56, 350

Click chemistry-based biomimetic ligands efficiently capture G-quadruplexes in vitroand help localize them at DNA damage sites in human cells, Francesco RotaSperti, Baptsite Dupouy, Jérémie Mitteaux, Angélique Pipier, Marc Pirrotta,Nicolas Chéron, Ibai E. Valverde, David Monchaud. JACS Au 2022, 2, 1588 

Interactions of small molecules with DNA junctions. Kane McQuaid, Angélique Pipier, Christine Cardin, David Monchaud. Nucleic Acids Res. 2022, 50, 12636

Global mapping of RNA G-quadruplexes (G4-RNAs) using G4RP-seq, Sunny Y. Yang, David Monchaud & Judy M. Y. Wong, Nat. Protoc. 2022, 17, 870

Identifying G-quadruplex-DNA–disrupting small molecules. J. Mitteaux, P. Lejault, F. Wojciechowski, A. Joubert, J. Boudon, N. Desbois, C. P. Gros, R. H. E. Hudson, J.-B. Boule, A. Granzhan, D. Monchaud. J. Am. Chem. Soc. 2021, 143, 12567

DNA junction ligands trigger DNA damage and are synthetic lethal with DNA repair inhibitors in cancer cells. K. Duskova, P. Lejault, E. Benchimol, R. Guillot,S. Britton, A. Granzhan, D. Monchaud J. Am. Chem. Soc. 2020, 142, 424

Applications of guanine-quartets in nanotechnology and chemical biology. L. Stefan, D. Monchaud Nat. Rev. Chem. 2019, 3, 650

Transcriptome-wide identification of transient RNA G-quadruplexes in human cells. S. Y. Yang, P. Lejault, S. Chevrier, R. Boidot, A. G. Robertson, J. M. Y. Wong, D. Monchaud Nat. Commun. 2018, 9, 4730

Thermophilic tetramolecular G-quadruplex/hemin DNAzyme. H. Ju, Y. Guo, J. Chen, M. Cheng, D. Monchaud, J. Zhou Angew. Chem. Int. Ed. 2017, 56, 16636

 

Shubham Sharma, Chinmayee Shukla, Jérémie Mitteaux, Angélique Pipier, Marc Pirrotta, et al.. G-quadruplex formation in long non-coding RNAs dysregulated in colorectal cancer. 2025. ⟨hal-05131642⟩
Leïla Dumas, Sauyeun Shin, Quentin Rigaud, Marie Cargnello, Beatriz Hernández-Suárez, et al.. RNA G-quadruplexes control mitochondria-localized mRNA translation and energy metabolism. Nature Communications, 2025, 16, pp.3292. ⟨10.1038/s41467-025-58118-5⟩. ⟨hal-05024071⟩
Shijiong Wei, Xiaobo Zhang, Yilong Feng, Shentong Tao, Dehui Qiu, et al.. Ultra-Specific G-Quadruplex–Colistin Interaction for Efficient Transcriptome-Wide G4 Mapping. Journal of the American Chemical Society, 2025, 147, pp.9962 - 9971. ⟨10.1021/jacs.5c01172⟩. ⟨hal-05018357⟩
Jiri Ledvinka, Francesco Rota Sperti, Gabor Paragi, Marc Pirrotta, Nicolas Chéron, et al.. Fluorescence Detection of DNA/RNA G‐Quadruplexes (G4s) by Twice‐as‐Smart Ligands. ChemMedChem, 2025, ⟨10.1002/cmdc.202400829⟩. ⟨hal-05018355⟩
David Monchaud, Angélique Pipier. Versatile Click Chemistry-based Approaches to Illuminate DNA and RNA G-Quadruplexes in Human Cells. Bio-protocol , 2025, 15 (3), pp.e5209. ⟨10.21769/bioprotoc.5209⟩. ⟨hal-04930089⟩
Maëlle Caroff, Aline Marnef, Angélique Pipier, Gaëlle Legube, Anton Granzhan, et al.. Ligand stabilization of DNA Three Way Junctions (TWJ) for targeted cancer therapy. Toulouse Onco Week, Feb 2025, Toulouse, France. ⟨hal-04930019⟩
Vijay Kumar M. J, Jeremie Mitteaux, Zi Wang, Ellery Wheeler, Nitin Tandon, et al.. Small molecule-based regulation of gene expression in human astrocytes switching on and off the G-quadruplex control systems. Journal of Biological Chemistry, 2025, 301 (1), pp.108040. ⟨10.1016/j.jbc.2024.108040⟩. ⟨hal-04870733⟩
Jérémie Mitteaux, David Monchaud. Protocol for cellular RNA G-quadruplex profiling using G4RP.v2. STAR Protocols, 2024, 5 (4), pp.103480. ⟨10.1016/j.xpro.2024.103480⟩. ⟨hal-04830486⟩
Giulia Nicoletto, Marianna Terreri, Ilaria Maurizio, Emanuela Ruggiero, Filippo M Cernilogar, et al.. G-quadruplexes in an SVA retrotransposon cause aberrant TAF1 gene expression in X-linked dystonia parkinsonism. Nucleic Acids Research, 2024, 52, pp.11571 - 11586. ⟨10.1093/nar/gkae797⟩. ⟨hal-04766424⟩
David Monchaud. Translating G-quadruplex ligands from bench to bedside: a Stephen Neidle's legacy. Medicinal Chemistry Research, In press, ⟨10.1007/s00044-024-03310-3⟩. ⟨hal-04692411⟩
Communications

>35 invited lectures ; >40 posters

Science popularization articles in Medecine/Sciences, Journal du CNRS and Encylopaedia Universalis

Highlights in CNRS News, CNRS, Science & Avenir and Pour La Science

Recommended by the F-1000 in 2011, 2013 et 2018

Covers for New J. Chem., Chem. Eur. J., Nucleic Acids Res., Eur. J. Org. Chem and RSC Chem. Biol.

In interview for CQFD, radio broadcast of the RTS (Radio Télévision Suisse): here

Training et Administration

Training

« Chemistry & nucleic acids » (2h/year, M2 MMHD, Dijon, since 2017).

« Chemistry & cancers » (2h/year, M2R SCM, Dijon, since 2017).

« Chemistry & translational research in oncology » (4h/an, EPHE Dijon, since 2012).

 

Administration

>500 reviewed articles for >80 different journals; cf. WoS profile

Jury for associate professor positions : 32MCF4173 (ICMUB, Dijon, 2013), 32MCF0246 (ICMUB, Dijon, 2012), 85MCF1850 (Université Paris Descartes, Paris, 2010), 32MCF0255 (ICMUB, Dijon, 2010).

Jury for HDR : R. Haudecoeur, DPM Grenoble, 2020; T. Caneque, Institut Curie, Paris, 2019; D. Gomez, IPBS Toulouse, 2017.

Jury for PhD thesis : Lab. D. Verga/JL. Mergny, IP Paris, 2023; Lab. S. Amrane, IECB Bordeaux 2022; Lab. T. Lavergne, UGA Grenoble, 2022; Lab. S. Ladame, Imperial College London (UK), 2021; Lab. C. Cruz Univ. Lisboa (PT) 2020; Lab. G. Salgado, IECB Bordeaux, 2019; Lab. O. Sénèque, CEA Grenobe, 2019; Lab. J.-L. Mergny, IECB Bordeaux, 2018 ; Lab. S. Richter, Unvi. Padova (IT), 2018; Lab. B. Therrien, Univ. Neuchatel (CH), 2018; Lab. M. Demeunynck, DPM Grenoble, 2016 ; Lab. J.-L. Mergny, IECB Bordeaux, 2016 ; Lab. F. Bolze, Strasbourg, 2015 ; Lab. R. Rodriguez, Gif/Yvette, 2015

Jury for Master 1 & 2 : ICMUB, Dijon, Juin 2021, 2020, 2012, 2013 & 2009 ; for M.Phil : Imperial College London (U.K.), Juin 2014.

Expert for funding agencies : European Research Council (ERC), Agence Nationale de la Recherche (ANR, France), Biotechnology and Biological Sciences Research Council (BBSRC, UK), Natural Sciences and Engineering Research Council (NSERC, Canada), Genesis Oncology Trust (New Zealand), Czech Academy of Science (CAS, Czech Republic), CEFIPRA (France & India), European Science Foundation (ESF, France).