Funding : 151 424 €
Duration : Feb 2022 – 54 months
PI ICMUB : Anthony ROMIEU (PI of the project)
Summary
In vivo synthetic chemistry defined as the use of cells as reaction vessels and their constituents as catalysts to achieve internal construction of molecular nano-objects, is a fascinating research field and is seen as having a great future potential for a plethora of biomedical applications. Our project aims to implement this attractive concept to the development of a novel, innovative and versatile fluorescence theranostic approach based on in situ formation of fluorophores from caged precursors and through biocompatible domino reactions, triggered by the constituents of cells and/or biomarker(s) related to a disease state (e.g., glycosidase enzymes). This fluorogenic reaction-based process will be accompanied by concomitant release of a drug molecule. Our probe design involving an effective molecular lego® approach will be also applied to the design of dual-functional drug delivery systems for combined pharmaco-photodynamic therapy (i.e., in situ formation of a ROS-generating photosensitizer and drug release).
Total fundings: 325 024 €
Partners:
- Institut de Chimie des Milieux et des Matériaux de Poitiers (IC2MP), UMR CNRS 7285, “Programmed Molecular Systems” (PMS) group, P.I.: Prof. Sébastien PAPOT
- Kévin RENAULT (Unité “Chimie et Modélisation pour la Biologie du Cancer, UMR CNRS 9187 – INSERM U 1196, Institut Curie, Orsay)